منابع مشابه
Immunoglobulin allotypes of the mouse.
morethanoneclassofheavychainflodd, 1963)couldonlyberationalized if these markers were present in the variable region. This has been the subject of muchcontroversy, as the presence of a genetic marker is indicative that the gene bearing it is present as only a single entity in the germ line, and hence an argument for somatic mutation as the mode of generation of antibody diversity. Sequence stud...
متن کاملImmunoglobulin allotypes in Crohn's disease in the Netherlands.
An association between Crohn's disease and immunoglobulin allotypes has been reported. Confirmation of this association in other populations would be of particular importance for the study of hereditary factors in Crohn's disease. In the present study we have typed 155 unrelated Dutch patients with Crohn's disease and 450 blood donors for the Gm, Am, and Km markers. No significant differences w...
متن کاملImmunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis.
Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.
متن کاملImmunoglobulin GM allotypes as effect modifiers of cytomegalovirus-spurred neuroblastoma.
An uncommon immunoglobulin GM (γ marker) genotype has been reported to be strongly associated with susceptibility to neuroblastoma, but the mechanism(s) underlying this association is not known. Increasing evidence implicates human cytomegalovirus (HCMV) in the pathogenesis of neuroblastoma. HCMV has evolved a large repertoire of sophisticated strategies to evade host immunosurveillance. Partic...
متن کاملImmunoglobulin allotypes in several North American Eskimo populations.
Genetic data consisting of immunoglobulin testing (GM and KM) from 631 Eskimos from 5 populations are reported. These populations are Savoonga, Gambell (St. Lawrence Island), Wales, King Island, and Mckenzie Delta, Baffin Island. The GM and KM haplotypes are analyzed and compared to those occurring in Greenland, Canadian, Alaskan, and Siberian Eskimos and to other Siberian indigenous population...
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ژورنال
عنوان ژورنال: mAbs
سال: 2009
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.1.4.9122